Publications from the group


An NMR Study of a 300-kDa AAA+ Unfoldase

Journal of Molecular Biology

Experiment-guided molecular simulations define a heterogeneous structural ensemble for the PTPN11 tandem SH2 domains

Chemical Science

A real-time analysis of GFP unfolding by the AAA+ unfoldase PAN

Journal of Magnetic Resonance

The EJC disassembly factor PYM is an intrinsically disordered protein and forms a fuzzy complex with RNA

Frontiers in Molecular Biosciences

Structural insights into the activity regulation of full-length non-structural protein 1 from SARS-CoV-2



Nucleic acid–protein interfaces studied by MAS solid-state NMR spectroscopy

Journal of Structural Biology:X


Identification of RNA Base Pairs and Complete Assignment of Nucleobase Resonances by Proton-Detected Solid-State NMR Spectroscopy at 100 kHz MAS

Angewandte Chemie International Edition

1H, 13C, and 15N backbone chemical-shift assignments of SARS-CoV-2 non-structural protein 1 (leader protein)

Biomolecular NMR Assignments

Eukaryotic Box C/D methylation machinery has two non-symmetric protein assembly sites

Scientific Reports

Phosphotyrosine couples peptide binding and SHP2 activation via a dynamic allosteric network

Computational and Structural Biology Journal

High-resolution structure of eukaryotic Fibrillarin interacting with Nop56 amino-terminal domain



Structural and functional roles of 2’-O-ribose methylations and their enzymatic machinery across multiple classes of RNAs

Current Opinion in Structural Biology

1H, 13C, 15N chemical shift assignments of SHP2 SH2 domains in complex with PD-1 immune-tyrosine motifs

Biomolecular NMR Assignments

Specificity and regulation of phosphotyrosine signaling through SH2 domains

Journal of Structural Biology: X

Structure of a Protein–RNA Complex by Solid-State NMR Spectroscopy

Angewandte Chemie International Edition

The guide sRNA sequence determines the activity level of box C/D RNPs


Small-Angle Neutron Scattering of RNA–Protein Complexes

Methods in Molecular Biology

Molecular mechanism of SHP2 activation by PD-1 stimulation

Science Advances


Histone chaperone exploits intrinsic disorder to switch acetylation specificity

Nature Communications

Solid-state NMR Spectroscopy of RNA

Methods in Enzymology


Rapid access to RNA resonances by proton-detected solid-state NMR at >100 kHz MAS

Chemical Communications

Isotope labeling for studying RNA by solid-state NMR spectroscopy

Journal of Biomolecular NMR

Structural characterization of the Asf1–Rtt109 interaction and its role in histone acetylation

Nucleic Acids Research


M3: an integrative framework for structure determination of molecular machines

Nature Methods

Structure-Based Design of Scaffolds Targeting PDE10A by INPHARMA-NMR

Journal of Chemical Information and Modeling


A bromodomain–DNA interaction facilitates acetylation-dependent bivalent nucleosome recognition by the BET protein BRDT

Nature Communications

Archaea box C/D enzymes methylate two distinct substrate rRNA sequences with different efficiency


The histone chaperone sNASP binds a conserved peptide motif within the globular core of histone H3 through its TPR repeats

Nucleic Acids Research

Optimization of protein samples for NMR using thermal shift assays

Journal of Biomolecular NMR


On-the-Fly Integration of Data from a Spin-Diffusion-Based NMR Experiment into Protein–Ligand Docking

Journal Of Chemical Information And Modeling

A Distinct, Sequence-Induced Conformation Is Required for Recognition of the Constitutive Decay Element RNA by Roquin


The structure of the SOLE element of oskar mRNA


Identification of new hit scaffolds by INPHARMA-guided virtual screening


RNA structure determination by solid-state NMR spectroscopy

Nature Communications


Present and future of NMR for RNA–protein complexes: A perspective of integrated structural biology

Journal of Magnetic Resonance


The structure of the box C/D enzyme reveals regulation of RNA methylation


A Suite of Solid-State NMR Experiments for RNA Intranucleotide Resonance Assignment in a 21 kDa Protein-RNA Complex

Angewandte Chemie International Edition

Accounting for Conformational Variability in Protein–Ligand Docking with NMR-Guided Rescoring

Journal of the American Chemical Society

Structural Principles of RNA Catalysis in a 2′–5′ Lariat-Forming Ribozyme

Journal of the American Chemical Society

Protein–RNA Interfaces Probed by 1H-Detected MAS Solid-State NMR Spectroscopy

Angewandte Chemie International Edition


The description of protein internal motions aids selection of ligand binding poses by the INPHARMA method

Journal of Biomolecular NMR

Understanding the Inhibitory Effect of Highly Potent and Selective Archazolides Binding to the Vacuolar ATPase

Journal Of Chemical Information And Modeling

NMR in natural products: understanding conformation, configuration and receptor interactions

Natural Product Reports

An NMR-based scoring function improves the accuracy of binding pose predictions by docking by two orders of magnitude

Journal of Biomolecular NMR


Recognition of 2′-O-Methylated 3′-End of piRNA by the PAZ Domain of a Piwi Protein



Structure of the K-turn U4 RNA: a combined NMR and SANS study

Nucleic Acids Research

The Tubulin-Bound Structure of the Antimitotic Drug Tubulysin

Angewandte Chemie International Edition

The Binding Mode of Side Chain- and C3-Modified Epothilones to Tubulin


Elucidation of the Structure and Intermolecular Interactions of a Reversible Cyclic-Peptide Inhibitor of the Proteasome by NMR Spectroscopy and Molecular Modeling

Angewandte Chemie International Edition

Intermolecular Protein−RNA Interactions Revealed by 2D 31P−15N Magic Angle Spinning Solid-State NMR Spectroscopy

Journal Of The American Chemical Society

Modular architecture of Munc13/calmodulin complexes: dual regulation by Ca2+ and possible function in short-term synaptic plasticity

EMBO Journal


The INPHARMA technique for pharmacophore mapping: A theoretical guide to the method

Journal of Magnetic Resonance

An Efficient Strategy for the Determination of the Three-Dimensional Architecture of Ribonucleoprotein Complexes by the Combination of a Few Easily Accessible NMR and Biochemical Data: Intermolecular Recognition in a U4 Spliceosomal Complex

Journal of Molecular Biology

Probing Mutation-Induced Structural Perturbations by Refinement Against Residual Dipolar Couplings: Application to the U4 Spliceosomal RNP Complex



NMR assignments of HIV-2 TAR RNA

Biomolecular NMR Assignments

Crystallography-Independent Determination of Ligand Binding Modes

Angewandte Chemie International Edition

Specific Methyl Group Protonation for the Measurement of Pharmacophore-Specific Interligand NOE Interactions

Chemistry: A European Journal

Simultaneous Determination of the Conformation and Relative Configuration of Archazolide A by Using Nuclear Overhauser Effects, J Couplings, and Residual Dipolar Couplings

Angewandte Chemie International Edition

Conformational preferences of natural and C3-modified epothilones in aqueous solution

Journal of Medicinal Chemistry


13C-Detection in RNA Bases:  Revealing Structure−Chemical Shift Relationships

Journal of the American Chemical Society

Binding of the Human Prp31 Nop Domain to a Composite RNA–Protein Platform in U4 snRNP


Structural Basis of the Activity of the Microtubule-Stabilizing Agent Epothilone A Studied by NMR Spectroscopy in Solution

Angewandte Chemie International Edition


The Tubulin-Bound Conformation of Discodermolide Derived by NMR Studies in Solution Supports a Common Pharmacophore Model for Epothilone and Discodermolide

Angewandte Chemie International Edition

Calculation of the Dependence of Homo- and Heteronuclear 3J and 2J Scalar Couplings for the Determination of the 2′-Hydroxy Conformation in RNA

Angewandte Chemie International Edition

SHARP-TACSY:  Triple-Band Tailored Correlated Spectroscopy for Base-to-Sugar Transfer in Nucleic Acid Residues with Intermediate Time Scale Motions

Journal of the American Chemical Society

TAR-RNA recognition by a novel cyclic aminoglycoside analogue

Nucleic Acids Research

Influence of the 2′-Hydroxyl Group Conformation on the Stability of A-form Helices in RNA

Journal of Molecular Biology


Side-Chain Orientation and Hydrogen-Bonding Imprint Supra-τc Motion on the Protein Backbone of Ubiquitin

Angewandte Chemie International Edition

The INPHARMA Method: Protein-Mediated Interligand NOEs for Pharmacophore Mapping

Angewandte Chemie International Edition

Ligand-Target Interactions: What Can We Learn from NMR?

Annual Review of Biophysics and Biomolecular Structure

Identification of a Novel Pharmacophore for Peptide Toxins Interacting with K+ Channels

Journal of Biological Chemistry

Assignment and NOE Analysis of 2'-Hydroxyl Protons in RNA:  Implications for Stabilization of RNA A-Form Duplexes

Journal of the American Chemical Society


κM-Conotoxin RIIIK, Structural and Functional Novelty in a K+ Channel Antagonist



Measuring the χ1 torsion angle in protein by CH-CH cross-correlated relaxation: A new resolution-optimised experiment

Journal Of Biomolecular NMR

Structural studies on a twin-arginine signal sequence

FEBS Letters

The High-Resolution Solution Structure of Epothilone A Bound to Tubulin: An Understanding of the Structure–Activity Relationships for a Powerful Class of Antitumor Agents

Angewandte Chemie International Edition

Derivation of Dihedral Angles from CH–CH Dipolar–Dipolar Cross-Correlated Relaxation Rates: A C–C Torsion Involving a Quaternary Carbon Atom in Epothilone A Bound to Tubulin

Angewandte Chemie International Edition


A novel PH-CT-COSY methodology for measuring JPH coupling constants in unlabeled nucleic acids. Application to HIV-2 TAR RNA

Journal of Biomolecular NMR


Determination of Aliphatic Side-Chain Conformation Using Cross-Correlated Relaxation:  Application to an Extraordinarily Stable 2‘-aminoethoxy-Modified Oligonucleotide Triplex

Journal of the American Chemical Society

COIN TACSY, a Novel Approach to Tailored Correlation Spectroscopy

Journal of Magnetic Resonance


A new method for the simultaneous measurement of magnitude and sign of 1DCH and 1DHH dipolar couplings in methylene groups

Journal of Biomolecular NMR

Errors in the Measurement of Cross-Correlated Relaxation Rates and How to Avoid Them

Journal of Magnetic Resonance

Ubiquitin Backbone Motion Studied via NHN−C‘Cα Dipolar−Dipolar and C‘−C‘Cα/NHN CSA−Dipolar Cross-Correlated Relaxation

Journal of the American Chemical Society


Transferred Cross-Correlated Relaxation: Application to the Determination of Sugar Pucker in an Aminoacylated tRNA-Mimetic Weakly Bound to EF-Tu

Journal of the American Chemical Society


New Methylene Specific Experiments for the Measurement of Scalar Spin–Spin Coupling Constants between Protons Attached to 13C

Journal of Magnetic Resonance


“Kin” HEHAHA Sequences, Heteronuclear Hartmann–Hahn Transfer with Different Bandwidths for Spins I and S

Journal of Magnetic Resonance

Resonance assignment and secondary structure determination and stability of the recombinant human uteroglobin with heteronuclear multidimensional NMR

Journal of Biomolecular NMR


PLUSH TACSY: Homonuclear planar TACSY with two-band selective shaped pulses applied to Cα,C′ transfer and Cβ,Caromatic correlations

Journal of Biomolecular NMR