Publications from the group
| Long-range conformational changes in the nucleotide-bound states of the DEAD-box helicase Vasa | Biophysical Journal |
| The specificity of intermodular recognition in a prototypical nonribosomal peptide synthetase depends on an adaptor domain | Science Advances |
| Phosphopeptide binding to the N-SH2 domain of tyrosine phosphatase SHP2 correlates with the unzipping of its central β-sheet | Computational and Structural Biology Journal |
| Methods for Structure Determination of SH2 Domain-Phosphopeptide Complexes by NMR | Methods in Molecular Biology |
| NMR Methods to Study the Dynamics of SH2 Domain-Phosphopeptide Complexes | Methods in Molecular Biology |
| An NMR Study of a 300-kDa AAA+ Unfoldase | Journal of Molecular Biology |
| Experiment-guided molecular simulations define a heterogeneous structural ensemble for the PTPN11 tandem SH2 domains | Chemical Science |
| A real-time analysis of GFP unfolding by the AAA+ unfoldase PAN | Journal of Magnetic Resonance |
| The EJC disassembly factor PYM is an intrinsically disordered protein and forms a fuzzy complex with RNA | Frontiers in Molecular Biosciences |
| Structural insights into the activity regulation of full-length non-structural protein 1 from SARS-CoV-2 | Structure |
| Nucleic acid–protein interfaces studied by MAS solid-state NMR spectroscopy | Journal of Structural Biology:X |
| Identification of RNA Base Pairs and Complete Assignment of Nucleobase Resonances by Proton-Detected Solid-State NMR Spectroscopy at 100 kHz MAS | Angewandte Chemie International Edition |
| 1H, 13C, and 15N backbone chemical-shift assignments of SARS-CoV-2 non-structural protein 1 (leader protein) | Biomolecular NMR Assignments |
| Eukaryotic Box C/D methylation machinery has two non-symmetric protein assembly sites | Scientific Reports |
| Phosphotyrosine couples peptide binding and SHP2 activation via a dynamic allosteric network | Computational and Structural Biology Journal |
| High-resolution structure of eukaryotic Fibrillarin interacting with Nop56 amino-terminal domain | RNA |
| Structural and functional roles of 2’-O-ribose methylations and their enzymatic machinery across multiple classes of RNAs | Current Opinion in Structural Biology |
| 1H, 13C, 15N chemical shift assignments of SHP2 SH2 domains in complex with PD-1 immune-tyrosine motifs | Biomolecular NMR Assignments |
| Specificity and regulation of phosphotyrosine signaling through SH2 domains | Journal of Structural Biology: X |
| Structure of a Protein–RNA Complex by Solid-State NMR Spectroscopy | Angewandte Chemie International Edition |
| The guide sRNA sequence determines the activity level of box C/D RNPs | eLife |
| Small-Angle Neutron Scattering of RNA–Protein Complexes | Methods in Molecular Biology |
| Molecular mechanism of SHP2 activation by PD-1 stimulation | Science Advances |
| Histone chaperone exploits intrinsic disorder to switch acetylation specificity | Nature Communications |
| Solid-state NMR Spectroscopy of RNA | Methods in Enzymology |
| Rapid access to RNA resonances by proton-detected solid-state NMR at >100 kHz MAS | Chemical Communications |
| Isotope labeling for studying RNA by solid-state NMR spectroscopy | Journal of Biomolecular NMR |
| Structural characterization of the Asf1–Rtt109 interaction and its role in histone acetylation | Nucleic Acids Research |
| M3: an integrative framework for structure determination of molecular machines | Nature Methods |
| Structure-Based Design of Scaffolds Targeting PDE10A by INPHARMA-NMR | Journal of Chemical Information and Modeling |
| On-the-Fly Integration of Data from a Spin-Diffusion-Based NMR Experiment into Protein–Ligand Docking | Journal Of Chemical Information And Modeling |
| A Distinct, Sequence-Induced Conformation Is Required for Recognition of the Constitutive Decay Element RNA by Roquin | Structure |
| The structure of the SOLE element of oskar mRNA | RNA |
| Identification of new hit scaffolds by INPHARMA-guided virtual screening | MedChemComm |
| RNA structure determination by solid-state NMR spectroscopy | Nature Communications |
| Present and future of NMR for RNA–protein complexes: A perspective of integrated structural biology | Journal of Magnetic Resonance |
| The structure of the box C/D enzyme reveals regulation of RNA methylation | Nature |
| A Suite of Solid-State NMR Experiments for RNA Intranucleotide Resonance Assignment in a 21 kDa Protein-RNA Complex | Angewandte Chemie International Edition |
| Accounting for Conformational Variability in Protein–Ligand Docking with NMR-Guided Rescoring | Journal of the American Chemical Society |
| Structural Principles of RNA Catalysis in a 2′–5′ Lariat-Forming Ribozyme | Journal of the American Chemical Society |
| Protein–RNA Interfaces Probed by 1H-Detected MAS Solid-State NMR Spectroscopy | Angewandte Chemie International Edition |
| The description of protein internal motions aids selection of ligand binding poses by the INPHARMA method | Journal of Biomolecular NMR |
| Understanding the Inhibitory Effect of Highly Potent and Selective Archazolides Binding to the Vacuolar ATPase | Journal Of Chemical Information And Modeling |
| NMR in natural products: understanding conformation, configuration and receptor interactions | Natural Product Reports |
| An NMR-based scoring function improves the accuracy of binding pose predictions by docking by two orders of magnitude | Journal of Biomolecular NMR |
| Recognition of 2′-O-Methylated 3′-End of piRNA by the PAZ Domain of a Piwi Protein | Structure |
| Structure of the K-turn U4 RNA: a combined NMR and SANS study | Nucleic Acids Research |
| The Tubulin-Bound Structure of the Antimitotic Drug Tubulysin | Angewandte Chemie International Edition |
| The Binding Mode of Side Chain- and C3-Modified Epothilones to Tubulin | ChemMedChem |
| Elucidation of the Structure and Intermolecular Interactions of a Reversible Cyclic-Peptide Inhibitor of the Proteasome by NMR Spectroscopy and Molecular Modeling | Angewandte Chemie International Edition |
| Intermolecular Protein−RNA Interactions Revealed by 2D 31P−15N Magic Angle Spinning Solid-State NMR Spectroscopy | Journal Of The American Chemical Society |
| Modular architecture of Munc13/calmodulin complexes: dual regulation by Ca2+ and possible function in short-term synaptic plasticity | EMBO Journal |
| NMR assignments of HIV-2 TAR RNA | Biomolecular NMR Assignments |
| Crystallography-Independent Determination of Ligand Binding Modes | Angewandte Chemie International Edition |
| Specific Methyl Group Protonation for the Measurement of Pharmacophore-Specific Interligand NOE Interactions | Chemistry: A European Journal |
| Simultaneous Determination of the Conformation and Relative Configuration of Archazolide A by Using Nuclear Overhauser Effects, J Couplings, and Residual Dipolar Couplings | Angewandte Chemie International Edition |
| Conformational preferences of natural and C3-modified epothilones in aqueous solution | Journal of Medicinal Chemistry |
| 13C-Detection in RNA Bases: Revealing Structure−Chemical Shift Relationships | Journal of the American Chemical Society |
| Binding of the Human Prp31 Nop Domain to a Composite RNA–Protein Platform in U4 snRNP | Science |
| Structural Basis of the Activity of the Microtubule-Stabilizing Agent Epothilone A Studied by NMR Spectroscopy in Solution | Angewandte Chemie International Edition |
| The Tubulin-Bound Conformation of Discodermolide Derived by NMR Studies in Solution Supports a Common Pharmacophore Model for Epothilone and Discodermolide | Angewandte Chemie International Edition |
| Calculation of the Dependence of Homo- and Heteronuclear 3J and 2J Scalar Couplings for the Determination of the 2′-Hydroxy Conformation in RNA | Angewandte Chemie International Edition |
| SHARP-TACSY: Triple-Band Tailored Correlated Spectroscopy for Base-to-Sugar Transfer in Nucleic Acid Residues with Intermediate Time Scale Motions | Journal of the American Chemical Society |
| TAR-RNA recognition by a novel cyclic aminoglycoside analogue | Nucleic Acids Research |
| Influence of the 2′-Hydroxyl Group Conformation on the Stability of A-form Helices in RNA | Journal of Molecular Biology |
| Side-Chain Orientation and Hydrogen-Bonding Imprint Supra-τc Motion on the Protein Backbone of Ubiquitin | Angewandte Chemie International Edition |
| The INPHARMA Method: Protein-Mediated Interligand NOEs for Pharmacophore Mapping | Angewandte Chemie International Edition |
| Ligand-Target Interactions: What Can We Learn from NMR? | Annual Review of Biophysics and Biomolecular Structure |
| Identification of a Novel Pharmacophore for Peptide Toxins Interacting with K+ Channels | Journal of Biological Chemistry |
| Assignment and NOE Analysis of 2'-Hydroxyl Protons in RNA: Implications for Stabilization of RNA A-Form Duplexes | Journal of the American Chemical Society |
| κM-Conotoxin RIIIK, Structural and Functional Novelty in a K+ Channel Antagonist | Biochemistry |
| Measuring the χ1 torsion angle in protein by CH-CH cross-correlated relaxation: A new resolution-optimised experiment | Journal Of Biomolecular NMR |
| Structural studies on a twin-arginine signal sequence | FEBS Letters |
| The High-Resolution Solution Structure of Epothilone A Bound to Tubulin: An Understanding of the Structure–Activity Relationships for a Powerful Class of Antitumor Agents | Angewandte Chemie International Edition |
| Derivation of Dihedral Angles from CH–CH Dipolar–Dipolar Cross-Correlated Relaxation Rates: A C–C Torsion Involving a Quaternary Carbon Atom in Epothilone A Bound to Tubulin | Angewandte Chemie International Edition |
| A novel PH-CT-COSY methodology for measuring JPH coupling constants in unlabeled nucleic acids. Application to HIV-2 TAR RNA | Journal of Biomolecular NMR |
| Determination of Aliphatic Side-Chain Conformation Using Cross-Correlated Relaxation: Application to an Extraordinarily Stable 2‘-aminoethoxy-Modified Oligonucleotide Triplex | Journal of the American Chemical Society |
| COIN TACSY, a Novel Approach to Tailored Correlation Spectroscopy | Journal of Magnetic Resonance |
| A new method for the simultaneous measurement of magnitude and sign of 1DCH and 1DHH dipolar couplings in methylene groups | Journal of Biomolecular NMR |
| Errors in the Measurement of Cross-Correlated Relaxation Rates and How to Avoid Them | Journal of Magnetic Resonance |
| Ubiquitin Backbone Motion Studied via NHN−C‘Cα Dipolar−Dipolar and C‘−C‘Cα/NHN CSA−Dipolar Cross-Correlated Relaxation | Journal of the American Chemical Society |
| Transferred Cross-Correlated Relaxation: Application to the Determination of Sugar Pucker in an Aminoacylated tRNA-Mimetic Weakly Bound to EF-Tu | Journal of the American Chemical Society |
| New Methylene Specific Experiments for the Measurement of Scalar Spin–Spin Coupling Constants between Protons Attached to 13C | Journal of Magnetic Resonance |
| “Kin” HEHAHA Sequences, Heteronuclear Hartmann–Hahn Transfer with Different Bandwidths for Spins I and S | Journal of Magnetic Resonance |
| Resonance assignment and secondary structure determination and stability of the recombinant human uteroglobin with heteronuclear multidimensional NMR | Journal of Biomolecular NMR |
| PLUSH TACSY: Homonuclear planar TACSY with two-band selective shaped pulses applied to Cα,C′ transfer and Cβ,Caromatic correlations | Journal of Biomolecular NMR |