Drug Design for G-Protein-Coupled Receptors by a Ligand-Based NMR Method
Angewandte Chemie International Edition 49, 1426–1429 (2010)
A nonradioactive binding assay relying on NMR methods has been devised for a G-protein-coupled receptor; in addition the INPHARMA methods give access to the relative orientation of multiple ligands and supports ligand-based drug design (see picture of superimposed ligands). The method is fast and does not require any structural information from protein crystal structures.