Long-range conformational changes in the nucleotide-bound states of the DEAD-box helicase Vasa |
Biophysical Journal
|
2024
|
The specificity of intermodular recognition in a prototypical nonribosomal peptide synthetase depends on an adaptor domain |
Science Advances
|
2024
|
Phosphopeptide binding to the N-SH2 domain of tyrosine phosphatase SHP2 correlates with the unzipping of its central Ī²-sheet |
Computational and Structural Biology Journal
|
2024
|
Methods for Structure Determination of SH2 DomaināPhosphopeptide Complexes by NMR |
Methods in Molecular Biology
|
2023
|
NMR Methods to Study the Dynamics of SH2 DomaināPhosphopeptide Complexes |
Methods in Molecular Biology
|
2023
|
An NMR Study of a 300-kDa AAA+ Unfoldase |
Journal of Molecular Biology
|
2023
|
Experiment-guided molecular simulations define a heterogeneous structural ensemble for the PTPN11 tandem SH2 domains |
Chemical Science
|
2023
|
A real-time analysis of GFP unfolding by the AAA+ unfoldase PAN |
Journal of Magnetic Resonance
|
2023
|
The EJC disassembly factor PYM is an intrinsically disordered protein and forms a fuzzy complex with RNA |
Frontiers in Molecular Biosciences
|
2023
|
Structural insights into the activity regulation of full-length non-structural protein 1 from SARS-CoV-2 |
Structure
|
2023
|
Nucleic acidāprotein interfaces studied by MAS solid-state NMR spectroscopy |
Journal of Structural Biology: X
|
2022
|
Identification of RNA Base Pairs and Complete Assignment of Nucleobase Resonances by Proton-Detected Solid-State NMR Spectroscopy at 100ā
kHz MAS |
Angewandte Chemie International Edition
|
2021
|
1H, 13C, and 15N backbone chemical-shift assignments of SARS-CoV-2 non-structural protein 1 (leader protein) |
Biomolecular NMR Assignments
|
2021
|
Eukaryotic Box C/D methylation machinery has two non-symmetric protein assembly sites |
Scientific Reports
|
2021
|
Recruitment of phospholipase CĪ³1 to the non-structural membrane protein pK15 of Kaposi Sarcoma-associated herpesvirus promotes its Src-dependent phosphorylation |
PLOS Pathogens
|
2021
|
Large-Scale Recombinant Production of the SARS-CoV-2 Proteome for High-Throughput and Structural Biology Applications |
Frontiers in Molecular Biosciences
|
2021
|
Phosphotyrosine couples peptide binding and SHP2 activation via a dynamic allosteric network |
Computational and Structural Biology Journal
|
2021
|
High-resolution structure of eukaryotic Fibrillarin interacting with Nop56 amino-terminal domain |
RNA
|
2021
|
Structural and functional roles of 2ā²-O-ribose methylations and their enzymatic machinery across multiple classes of RNAs |
Current Opinion in Structural Biology
|
2020
|
1H, 13C, 15N chemical shift assignments of SHP2 SH2 domains in complex with PD-1 immune-tyrosine motifs |
Biomolecular NMR Assignments
|
2020
|
Observing Protein Degradation by the PAN-20S Proteasome by Time-Resolved Neutron Scattering |
Biophysical Journal
|
2020
|
Specificity and regulation of phosphotyrosine signaling through SH2 domains |
Journal of Structural Biology: X
|
2020
|
Structure of a ProteināRNA Complex by Solid-State NMR Spectroscopy |
Angewandte Chemie International Edition
|
2020
|
The guide sRNA sequence determines the activity level of box C/D RNPs |
eLife
|
2020
|
Small-Angle Neutron Scattering of RNAāProtein Complexes |
Methods in Molecular Biology
|
2020
|
Molecular mechanism of SHP2 activation by PD-1 stimulation |
Science Advances
|
2020
|
Molecular mechanism of SHP2 activation by PD-1 stimulation |
Science Advances
|
2020
|
Histone chaperone exploits intrinsic disorder to switch acetylation specificity |
Nature Communications
|
2019
|
Solid-state NMR Spectroscopy of RNA |
Methods in Enzymology
|
2018
|
Rapid access to RNA resonances by proton-detected solid-state NMR at >100 kHz MAS |
Chemical Communications
|
2018
|
Isotope labeling for studying RNA by solid-state NMR spectroscopy |
Journal of Biomolecular NMR
|
2018
|
Structural characterization of the Asf1āRtt109 interaction and its role in histone acetylation |
Nucleic Acids Research
|
2018
|
Chemical Analysis of a "Miller-Type" Complex Prebiotic Broth |
Origins of Life and Evolution of Biospheres
|
2017
|
M3: an integrative framework for structure determination of molecular machines |
Nature Methods
|
2017
|
Structure-Based Design of Scaffolds Targeting PDE10A by INPHARMA-NMR |
Journal of Chemical Information and Modeling
|
2017
|
A bromodomaināDNA interaction facilitates acetylation-dependent bivalent nucleosome recognition by the BET protein BRDT |
Nature Communications
|
2016
|
RflM mediates target specificity of the RcsCDB phosphorelay system for transcriptional repression of flagellar synthesis in Salmonella enterica |
Molecular Microbiology
|
2016
|
Chemical Analysis of a "Miller-Type" Complex Prebiotic Broth Part I: Chemical Diversity, Oxygen and Nitrogen Based Polymers |
Origins of Life and Evolution of Biospheres
|
2016
|
Archaea box C/D enzymes methylate two distinct substrate rRNA sequences with different efficiency |
RNA
|
2016
|
The histone chaperone sNASP binds a conserved peptide motif within the globular core of histone H3 through its TPR repeats |
Nucleic Acids Research
|
2016
|
Optimization of protein samples for NMR using thermal shift assays |
Journal of Biomolecular NMR
|
2016
|
On-the-Fly Integration of Data from a Spin-Diffusion-Based NMR Experiment into ProteināLigand Docking |
Journal of Chemical Information and Modeling
|
2015
|
A Distinct, Sequence-Induced Conformation Is Required for Recognition of the Constitutive Decay Element RNA by Roquin |
Structure
|
2015
|
The structure of the SOLE element of oskar mRNA |
RNA
|
2015
|
Identification of new hit scaffolds by INPHARMA-guided virtual screening |
MedChemComm
|
2015
|
RNA structure determination by solid-state NMR spectroscopy |
Nature Communications
|
2015
|
An integrated approach for genome annotation of the eukaryotic thermophile Chaetomium thermophilum |
Nucleic Acids Research
|
2014
|
Six Subgroups and Extensive Recent Duplications Characterize the Evolution of the Eukaryotic Tubulin Protein Family |
Genome Biology and Evolution
|
2014
|
Molecular Recognition of Epothilones by Microtubules and Tubulin Dimers Revealed by Biochemical and NMR Approaches |
ACS Chemical Biology
|
2014
|
Present and future of NMR for RNAāprotein complexes: A perspective of integrated structural biology |
Journal of Magnetic Resonance
|
2014
|
The structure of the box C/D enzyme reveals regulation of RNA methylation |
Nature
|
2013
|
A Reducing Milieu Renders Cofilin Insensitive to Phosphatidylinositol 4,5-Bisphosphate (PIP2) Inhibition |
Journal of Biological Chemistry
|
2013
|
A Suite of Solid-State NMR Experiments for RNA Intranucleotide Resonance Assignment in a 21 kDa Protein-RNA Complex |
Angewandte Chemie International Edition
|
2013
|
Accounting for Conformational Variability in ProteināLigand Docking with NMR-Guided Rescoring |
Journal of the American Chemical Society
|
2013
|
Structural Principles of RNA Catalysis in a 2ā²ā5ā² Lariat-Forming Ribozyme |
Journal of the American Chemical Society
|
2013
|
Towards Improved Quality of GPCR Models by Usage of Multiple Templates and Profile-Profile Comparison |
PLOS ONE
|
2013
|
ProteināRNA Interfaces Probed by 1H-Detected MAS Solid-State NMR Spectroscopy |
Angewandte Chemie International Edition
|
2013
|
Synthesis and biological evaluation of a water-soluble derivative of the potent V-ATPase inhibitor archazolid |
Bioorganic & Medicinal Chemistry Letters
|
2012
|
Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity |
Nature Structural and Molecular Biology
|
2012
|
The description of protein internal motions aids selection of ligand binding poses by the INPHARMA method |
Journal of Biomolecular NMR
|
2012
|
Understanding the Inhibitory Effect of Highly Potent and Selective Archazolides Binding to the Vacuolar ATPase |
Journal of Chemical Information and Modeling
|
2012
|
Hyperpolarized Binding Pocket Nuclear Overhauser Effect for Determination of Competitive Ligand Binding |
Angewandte Chemie International Edition
|
2012
|
NMR in natural products: understanding conformation, configuration and receptor interactions |
Natural Product Reports
|
2012
|
An NMR-based scoring function improves the accuracy of binding pose predictions by docking by two orders of magnitude |
Journal of Biomolecular NMR
|
2012
|
Computational techniques are valuable tools for the discovery of proteināprotein interaction inhibitors: The 14-3-3Ļ case |
Bioorganic & Medicinal Chemistry Letters
|
2011
|
Recognition of 2ā²-O-Methylated 3ā²-End of piRNA by the PAZ Domain of a Piwi Protein |
Structure
|
2011
|
Interaction of Epothilone B (Patupilone) with Microtubules as Detected by Two-Dimensional Solid-State NMR Spectroscopy |
Angewandte Chemie International Edition
|
2010
|
Structure of the K-turn U4 RNA: a combined NMR and SANS study |
Nucleic Acids Research
|
2010
|
Peptide Ligands Selected with CD4-Induced Epitopes on Native Dualtropic HIV-1 Envelope Proteins Mimic Extracellular Coreceptor Domains and Bind to HIV-1 gp120 Independently of Coreceptor Usage |
Journal of Virology
|
2010
|
The Tubulin-Bound Structure of the Antimitotic Drug Tubulysin |
Angewandte Chemie International Edition
|
2010
|
Synthesis and Biological Characterization of Argyrinā
F |
ChemMedChem
|
2010
|
The Binding Mode of Side Chain- and C3-Modified Epothilones to Tubulin |
ChemMedChem
|
2010
|
Elucidation of the Structure and Intermolecular Interactions of a Reversible Cyclic-Peptide Inhibitor of the Proteasome by NMR Spectroscopy and Molecular Modeling |
Angewandte Chemie International Edition
|
2010
|
1H, 13C and 15N resonance assignments of the Calmodulin-Munc13-1 peptide complex |
Biomolecular NMR Assignments
|
2010
|
Intermolecular ProteināRNA Interactions Revealed by 2D 31Pā15N Magic Angle Spinning Solid-State NMR Spectroscopy |
Journal of the American Chemical Society
|
2010
|
Drug Design for G-Protein-Coupled Receptors by a Ligand-Based NMR Method |
Angewandte Chemie International Edition
|
2010
|
Modular architecture of Munc13/calmodulin complexes: dual regulation by Ca2+ and possible function in short-term synaptic plasticity |
EMBO Journal
|
2010
|
The INPHARMA technique for pharmacophore mapping: A theoretical guide to the method |
Journal of Magnetic Resonance
|
2009
|
An Efficient Strategy for the Determination of the Three-Dimensional Architecture of Ribonucleoprotein Complexes by the Combination of a Few Easily Accessible NMR and Biochemical Data: Intermolecular Recognition in a U4 Spliceosomal Complex |
Journal of Molecular Biology
|
2009
|
Probing Mutation-Induced Structural Perturbations by Refinement Against Residual Dipolar Couplings: Application to the U4 Spliceosomal RNP Complex |
ChemBioChem
|
2009
|
NMR assignments of HIV-2 TAR RNA |
Biomolecular NMR Assignments
|
2008
|
Crystallography-Independent Determination of Ligand Binding Modes |
Angewandte Chemie International Edition
|
2008
|
Specific Methyl Group Protonation for the Measurement of Pharmacophore-Specific Interligand NOE Interactions |
Chemistry: A European Journal
|
2008
|
Studies of dynamic nuclear polarization with nitroxides in aqueous solution |
Applied Magnetic Resonance
|
2008
|
Construction of a liquid-state NMR DNP shuttle spectrometer: First experimental results and evaluation of optimal performance characteristics |
Applied Magnetic Resonance
|
2008
|
Argyrin A Reveals a Critical Role for the Tumor Suppressor Protein p27kip1 in Mediating Antitumor Activities in Response to Proteasome Inhibition |
Cancer Cell
|
2008
|
Simultaneous Determination of the Conformation and Relative Configuration of Archazolideā
A by Using Nuclear Overhauser Effects, J Couplings, and Residual Dipolar Couplings |
Angewandte Chemie International Edition
|
2008
|
Field dependent dynamic nuclear polarization with radicals in aqueous solution |
Journal of the American Chemical Society
|
2008
|
Conformational preferences of natural and C3-modified epothilones in aqueous solution |
Journal of Medicinal Chemistry
|
2008
|
13C-Detection in RNA Bases:ā Revealing StructureāChemical Shift Relationships |
Journal of the American Chemical Society
|
2007
|
Binding of the Human Prp31 Nop Domain to a Composite RNAāProtein Platform in U4 snRNP |
Science
|
2007
|
High-Resolution Solid-State NMR Structure of an Anticancer Agent |
ChemMedChem
|
2007
|
Structural Basis of the Activity of the Microtubule-Stabilizing Agent Epothiloneā
A Studied by NMR Spectroscopy in Solution |
Angewandte Chemie International Edition
|
2007
|
The Tubulin-Bound Conformation of Discodermolide Derived by NMR Studies in Solution Supports a Common Pharmacophore Model for Epothilone and Discodermolide |
Angewandte Chemie International Edition
|
2006
|
Calculation of the Dependence of Homo- and Heteronuclear 3J and 2J Scalar Couplings for the Determination of the 2ā²-Hydroxy Conformation in RNA |
Angewandte Chemie International Edition
|
2006
|
Stereochemical Determination of Archazolid A and B, Highly Potent Vacuolar-Type ATPase Inhibitors from the Myxobacterium Archangium gephyra |
Organic Letters
|
2006
|
SHARP-TACSY:ā Triple-Band Tailored Correlated Spectroscopy for Base-to-Sugar Transfer in Nucleic Acid Residues with Intermediate Time Scale Motions |
Journal of the American Chemical Society
|
2006
|
TAR-RNA recognition by a novel cyclic aminoglycoside analogue |
Nucleic Acids Research
|
2006
|
Influence of the 2ā²-Hydroxyl Group Conformation on the Stability of A-form Helices in RNA |
Journal of Molecular Biology
|
2006
|
A Thorough Dynamic Interpretation of Residual Dipolar Couplings in Ubiquitin |
Journal of Biomolecular NMR
|
2006
|
Side-Chain Orientation and Hydrogen-Bonding Imprint Supra-Ļc Motion on the Protein Backbone of Ubiquitin |
Angewandte Chemie International Edition
|
2005
|
The INPHARMA Method: Protein-Mediated Interligand NOEs for Pharmacophore Mapping |
Angewandte Chemie International Edition
|
2005
|
LigandāTarget Interactions: What Can We Learn from NMR? |
Annual Review of Biophysics
|
2005
|
Identification of a Novel Pharmacophore for Peptide Toxins Interacting with K+ Channels |
Journal of Biological Chemistry
|
2005
|
Assignment and NOE Analysis of 2'-Hydroxyl Protons in RNA:ā Implications for Stabilization of RNA A-Form Duplexes |
Journal of the American Chemical Society
|
2005
|
ĪŗM-Conotoxin RIIIK, Structural and Functional Novelty in a K+ Channel Antagonist |
Biochemistry
|
2004
|
Structure of the NCoA-1/SRC-1 PAS-B Domain Bound to the LXXLL Motif of the STAT6 Transactivation Domain |
Journal of Molecular Biology
|
2004
|
Measuring the Ļ1 torsion angle in protein by CH-CH cross-correlated relaxation: A new resolution-optimised experiment |
Journal of Biomolecular NMR
|
2003
|
Structural studies on a twin-arginine signal sequence |
FEBS Letters
|
2003
|
The High-Resolution Solution Structure of Epothilone A Bound to Tubulin: An Understanding of the StructureāActivity Relationships for a Powerful Class of Antitumor Agents |
Angewandte Chemie International Edition
|
2003
|
Derivation of Dihedral Angles from CHāCH DipolarāDipolar Cross-Correlated Relaxation Rates: A CāC Torsion Involving a Quaternary Carbon Atom in Epothilone A Bound to Tubulin |
Angewandte Chemie International Edition
|
2003
|
A novel PH-CT-COSY methodology for measuring JPH coupling constants in unlabeled nucleic acids. Application to HIV-2 TAR RNA |
Journal of Biomolecular NMR
|
2002
|
Determination of Aliphatic Side-Chain Conformation Using Cross-Correlated Relaxation:ā Application to an Extraordinarily Stable 2ā²-aminoethoxy-Modified Oligonucleotide Triplex |
Journal of the American Chemical Society
|
2001
|
Residual Dipolar Coupling TOCSY for Direct Through Space Correlations of Base Protons and Phosphorus Nuclei in RNA |
Journal of the American Chemical Society
|
2001
|
COIN TACSY, a Novel Approach to Tailored Correlation Spectroscopy |
Journal of Magnetic Resonance
|
2001
|
Cross-Correlated Relaxation for Measurement of Angles between Tensorial Interactions |
Methods in Enzymology
|
2001
|
A new method for the simultaneous measurement of magnitude and sign of 1DCH and 1DHH dipolar couplings in methylene groups |
Journal of Biomolecular NMR
|
2000
|
Errors in the Measurement of Cross-Correlated Relaxation Rates and How to Avoid Them |
Journal of Magnetic Resonance
|
2000
|
Ubiquitin Backbone Motion Studied via NHNāCāCĪ± DipolarāDipolar and CāāCāCĪ±/NHN CSAāDipolar Cross-Correlated Relaxation |
Journal of the American Chemical Society
|
2000
|
TransferredāCross-CorrelatedāRelaxation:āApplication to the Determination of Sugar Pucker in an Aminoacylated tRNA-Mimetic Weakly Bound to EF-Tu |
Journal of the American Chemical Society
|
1999
|
New Methylene Specific Experiments for the Measurement of Scalar SpināSpin Coupling Constants between Protons Attached to 13C |
Journal of Magnetic Resonance
|
1998
|
āKinā HEHAHA Sequences, Heteronuclear HartmannāHahn Transfer with Different Bandwidths for Spins I and S |
Journal of Magnetic Resonance
|
1997
|
Resonance assignment and secondary structure determination and stability of the recombinant human uteroglobin with heteronuclear multidimensional NMR |
Journal of Biomolecular NMR
|
1997
|
PLUSH TACSY: Homonuclear planar TACSY with two-band selective shaped pulses applied to CĪ±,Cā² transfer and CĪ²,Caromatic correlations |
Journal of Biomolecular NMR
|
1996
|
Conformational analysis of Dolastatin 10: An NMR and theoretical approach |
Biopolymers
|
1995
|