Side-Chain Orientation and Hydrogen-Bonding Imprint Supra-Οc Motion on the Protein Backbone of Ubiquitin
Angewandte Chemie International Edition 44, 7776β7778 (2005)
Order parameters derived from residual dipolar couplings between NH groups reveal motion of protein backbones on a time scale slower than the correlation time ΟC. Less-mobile amides (blue and green) in ubiquitin, for example, are H-bonded and belong to residues with side chains pointing towards the hydrophobic core while more mobile ones (yellow, orange, and red) have solvent-exposed side chains and fewer H bonds.