Dr John Kirkpatrick

Joined the group

Publications within the group:


2021
Identification of RNA Base Pairs and Complete Assignment of Nucleobase Resonances by Proton-Detected Solid-State NMR Spectroscopy at 100 kHz MAS

Angewandte Chemie International Edition

1H, 13C, and 15N backbone chemical-shift assignments of SARS-CoV-2 non-structural protein 1 (leader protein)

Biomolecular NMR Assignments

Large-Scale Recombinant Production of the SARS-CoV-2 Proteome for High-Throughput and Structural Biology Applications

Frontiers in Molecular Biosciences

Phosphotyrosine couples peptide binding and SHP2 activation via a dynamic allosteric network

Computational and Structural Biology Journal


2020
1H, 13C, 15N chemical shift assignments of SHP2 SH2 domains in complex with PD-1 immune-tyrosine motifs

Biomolecular NMR Assignments

The guide sRNA sequence determines the activity level of box C/D RNPs

eLife

Molecular mechanism of SHP2 activation by PD-1 stimulation

Science Advances


2019
Histone chaperone exploits intrinsic disorder to switch acetylation specificity

Nature Communications


2018
Structural characterization of the Asf1–Rtt109 interaction and its role in histone acetylation

Nucleic Acids Research


2011
Recognition of 2′-O-Methylated 3′-End of piRNA by the PAZ Domain of a Piwi Protein

Structure


2010
Intermolecular Protein−RNA Interactions Revealed by 2D 31P−15N Magic Angle Spinning Solid-State NMR Spectroscopy

Journal Of The American Chemical Society


2009
An Efficient Strategy for the Determination of the Three-Dimensional Architecture of Ribonucleoprotein Complexes by the Combination of a Few Easily Accessible NMR and Biochemical Data: Intermolecular Recognition in a U4 Spliceosomal Complex

Journal of Molecular Biology

Probing Mutation-Induced Structural Perturbations by Refinement Against Residual Dipolar Couplings: Application to the U4 Spliceosomal RNP Complex

ChemBioChem