The 3D solid-state NMR structure of Epothilone B. Solid-state Nuclear Magnetic Resonance (ssNMR) has recently made significant progress in probing molecular structures. Epothilones are natural compounds produced by the myxobacterium Sorangium cellulosum and exhibit high cytotoxic activity against multiresistant tumor cells. Herein, we show that two 2D CHHC correlation experiments are sufficient to rapidly assemble a high-resolution structure of Epothilone B.