Lukas Lercher


Lukas did his undergrad at the LMU, Munich in Biochemistry, focusing on physical, organic and biochemistry. He completed his master thesis in the lab of Prof. T Carell, working on novel methods for 5-meC sequencing.  After a brief stint at the Technion in Haifa, working on organometallic chemistry with Prof. I Marek, he moved to the University of Oxford in 2010 to start his PhD in chemical biology with Prof. BG Davis and Prof. CJ Schofield. Here, he spent most of his time working on DNA and protein modification methodology and studying the effect of protein PTMs on structure and dynamics. During this time, a stay at the SGC in Toronto, in the lab of Dr. J Min, cemented his interest in protein structure. A collaboration with Prof. AJ Baldwin sparked his interest in protein NMR, which he decided to pursue for his post-doc, in the Carlomagno lab. He is currently working on chaperone assisted histone folding and regulation of enzyme activity by chaperone association.

In his spare time he enjoys going climbing, music and the occasional pint.


Chemical biology, chemical protein modification, PTMs, epigenetics




Dumas A, Lercher L, Spicer CD, Davis BG

Designing logical codon reassignment - Expanding the chemistry in biology.

Chem Sci. 2015 Jan 01;6(1):50-69. doi: link


Lercher L, McDonough MA, El-Sagheer AH, Thalhammer A, Kriaucionis S, Brown T, Schofield CJ

Structural insights into how 5-hydroxymethylation influences transcription factor binding.

Chem Commun (Camb). 2014 Feb 21;50(15):1794-6. doi: link


Lercher L, McGouran JF, Kessler BM, Schofield CJ, Davis BG

DNA modification under mild conditions by Suzuki-Miyaura cross-coupling for the generation of functional probes.

Angew Chem Int Ed Engl. 2013 Sep 27;52(40):10553-8. doi: link

Lin YA, Boutureira O, Lercher L, Bhushan B, Paton RS, Davis BG

Rapid cross-metathesis for reversible protein modifications via chemical access to Se-allyl-selenocysteine in proteins.

J Am Chem Soc. 2013 Aug 21;135(33):12156-9. doi: link

Minko Y, Pasco M, Lercher L, Marek I

Stereodefined trisubstituted enolates as a unique entry to all-carbon quaternary stereogenic centers in acyclic systems.

Nat Protoc. 2013 Apr;8(4):749-54. doi: link


Minko Y, Pasco M, Lercher L, Botoshansky M, Marek I

Forming all-carbon quaternary stereogenic centres in acyclic systems from alkynes.

Nature. 2012 Oct 25;490(7421):522-6. doi: link

Chalker JM, Lercher L, Rose NR, Schofield CJ, Davis BG

Conversion of cysteine into dehydroalanine enables access to synthetic histones bearing diverse post-translational modifications.

Angew Chem Int Ed Engl. 2012 Feb 20;51(8):1835-9. doi: link


Munzel M, Lercher L, Muller M, Carell T

Chemical discrimination between dC and 5MedC via their hydroxylamine adducts.

Nucleic Acids Res. 2010 Nov;38(21):e192. doi: link


Chuprakov S, Kwok SW, Zhang L, Lercher L, Fokin VV

Rhodium-catalyzed enantioselective cyclopropanation of olefins with N-sulfonyl 1,2,3-triazoles.

J Am Chem Soc. 2009 Dec 23;131(50):18034-5. doi: link