Luca Codutti

Summary

I am an NMR spectroscopist with biotechnological backgrounds. Currently I am working with the structural characterization of RNA binding proteins and the determination of the binding of fragment ligands to proteins of pharmaceutical interest, such as Kinases and Phosphodiestherases and GPCR.
 

Specialties:

• Nuclear magnetic resonance NMR
• Expression of recombinant proteins in bacterial systems (E.coli) 
• Protein purification using FPLC chromatographers 
• Molecular biology 
• quantitative assays
• Molecular Modelling, Molecular dynamics
• Extensive knowledge of Python and scientific python libraries (numpy, scipy, matplotlib)

Publications:

2013

Skjaerven L, Codutti L, Angelini A, Grimaldi M, Latek D, Monecke P, Dreyer MK, Carlomagno T

Accounting for conformational variability in protein-ligand docking with NMR-guided rescoring.

J Am Chem Soc. 2013 Apr 17;135(15):5819-27. doi: link


Carlomagno T, Amata I, Codutti L, Falb M, Fohrer J, Masiewicz P, Simon B

Structural principles of RNA catalysis in a 2'-5' lariat-forming ribozyme.

J Am Chem Soc. 2013 Mar 20;135(11):4403-11. doi: link


2012

Rennella E, Corazza A, Codutti L, Causero A, Bellotti V, Stoppini M, Viglino P, Fogolari F, Esposito G

Single-shot NMR measurement of protein unfolding landscapes.

Biochim Biophys Acta. 2012 Jun;1824(6):842-9. doi: link


Rennella E, Corazza A, Codutti L, Bellotti V, Stoppini M, Viglino P, Fogolari F, Esposito G

Determining the energy landscape of proteins by a fast isotope exchange NMR approach.

J Am Chem Soc. 2012 Mar 14;134(10):4457-60. doi: link


2011

Fogolari F, Corazza A, Varini N, Rotter M, Gumral D, Codutti L, Rennella E, Viglino P, Bellotti V, Esposito G

Molecular dynamics simulation of beta(2)-microglobulin in denaturing and stabilizing conditions.

Proteins. 2011 Mar;79(3):986-1001. doi: link


Giorgetti S, Raimondi S, Pagano K, Relini A, Bucciantini M, Corazza A, Fogolari F, Codutti L, Salmona M, Mangione P, Colombo L, De Luigi A, Porcari R, Gliozzi A, Stefani M, Esposito G, Bellotti V, Stoppini M

Effect of tetracyclines on the dynamics of formation and destructuration of beta2-microglobulin amyloid fibrils.

J Biol Chem. 2011 Jan 21;286(3):2121-31. doi: link


2009

Codutti L, Picotti P, Marin O, Dewilde S, Fogolari F, Corazza A, Viglino P, Moens L, Esposito G, Fontana A

Conformational stability of neuroglobin helix F--possible effects on the folding pathway within the globin family.

FEBS J. 2009 Sep;276(18):5177-90. doi: link


2008

Codutti L, van Ingen H, Vascotto C, Fogolari F, Corazza A, Tell G, Quadrifoglio F, Viglino P, Boelens R, Esposito G

The solution structure of DNA-free Pax-8 paired box domain accounts for redox regulation of transcriptional activity in the pax protein family.

J Biol Chem. 2008 Nov 28;283(48):33321-8. doi: link